منابع مشابه
Macromolecular crowding modulates folding mechanism of alpha/beta protein apoflavodoxin.
Protein dynamics in cells may be different from those in dilute solutions in vitro, because the environment in cells is highly concentrated with other macromolecules. This volume exclusion because of macromolecular crowding is predicted to affect both equilibrium and kinetic processes involving protein conformational changes. To quantify macromolecular crowding effects on protein folding mechan...
متن کاملGlobal stimulus configuration modulates crowding.
In crowding, neighboring elements impair the perception of a peripherally presented target. Crowding is often regarded to be a consequence of spatial pooling of information that leads to the perception of textural wholes. We studied the effects of stimulus configuration on crowding using Gabor stimuli. In accordance with previous studies, contrast and orientation discrimination of a Gabor targe...
متن کاملCategorical membership modulates crowding: evidence from characters.
Visual crowding is generally thought to affect recognition mostly or only at the level of feature combination. Calling this assertion into question, recent studies have shown that if a target object and its flankers belong to different categories crowding is weaker than if they belong to the same category. Nevertheless, these results can be explained in terms of featural differences between cat...
متن کاملHuman Glycolipid Transfer Protein (GLTP) Expression Modulates Cell Shape
Glycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2). Although GLTP-folds are known to play roles in the nonvesicular intracellular trafficking of ...
متن کاملA Didactic Model of Macromolecular Crowding Effects on Protein Folding
A didactic model is presented to illustrate how the effect of macromolecular crowding on protein folding and association is modeled using current analytical theory and discrete molecular dynamics. While analytical treatments of crowding may consider the effect as a potential of average force acting to compress a polypeptide chain into a compact state, the use of simulations enables the presence...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1810054115